That's 7.3M pixels that your 2080 will have to push which is 2 WQHD monitors side-by-side (2550x1440). Aerofly will probably still run smooth but you might encounter low frame rates with Car Racing sims and MSFS.
Like I said, I've never tried VR. Now I'm considering buying the new HP Reverb G2 VR.
https://store.steampowered.com/app/1271440/HP_Reverb_G2/
It says, quote:
QuoteABOUT THIS HARDWARE
Resolution: Immerse yourself in ultra sharp visuals with mura-free, 2160 x 2160 LCD panels per eye and full RGB stripe.
Will this also be too many pixels - or will it work great with AFS2?