Revisiting this thread, I am happy to report that my YOKO yoke is working great in FS2!
A couple of weeks ago, I was using the yoke in that "other sim" and noticed some weird jittering in the onscreen yoke whenever I moved my physical yoke to the limits of it's axes. After a few emails to the manufacturer, it was determined that I had a bad circuit board (a small board that the USB cable plugs into). They sent me a replacement board with updated firmware. I installed the new board, calibrated the yoke and the issue was resolved...…..YAY!
My next thought was, let's try it now in FS2.
Bingo! So the issue was never with the sim, it was hardware.