Almost all aircraft fall into one of four categories: Single engine, twin engine propeller, twin-jet engine and quad-jet-engine aircraft. We also have a helicopter category. These categories allow you to re-use the same configuration for similar aircraft.
This makes it possible to have one layout for propeller aircraft like the Q400, King Air, Baron 58 and have a different setup for twin jets like the A320, B737, B777, B787, Learjet, etc. And you don't need to switch between profiles, it just works.
As an example, I have four levers on my throttle quadrant.
On a twin jet the middle two control my thrust levers, the left one airbrake and the right one flaps.
On a twin propeller the middle two control power levers, the left one propeller speed and right one flaps.
Basically, the different settings you mentioned work quite well.
Unfortunately, two settings for single-engine aircraft override those for multi-engine aircraft:
- Engine master 
- Engine start
